Understanding the role of oxidative stress in membrane signaling of aged cells

Anant Verma

G-protein coupled receptors are transmembrane proteins responsible for many important functions such as signalling, hormone activation, immune response, etc. CXCR4 is a GPCR receptor involved in signalling and binds with the ligand CXCL12. Oxidative stress results in upregulation of reactive oxidant species in and around the cell leading to formation of lipid free radicals which modifies DNA, damages mitochondria and other organelles. The project focuses on the loss of signalling in aging cells due to failure of CXCR4 functioning. The goal is to identify why and how this signalling mechanism fails with the use of molecular dynamics simulations of the plasma membrane under oxidative stress.